2 edition of Synthesis of natural products via intramolecular trapping of photogenerated ketenes. found in the catalog.
Synthesis of natural products via intramolecular trapping of photogenerated ketenes.
John Alexander Winders
PhD thesis, Chemistry.
The manipulation of this moiety has had a significant role in twentieth century organic chemistry. Ketenes as intermediates have helped in advancing the art of total syntheses of natural products (CSR, EJO), and led to the development of some name reactions (MI, T7, CUOC, T). The cover picture shows a model of the cluster [Cu 29 Te 16 (Pi Pr 3) 12], whose structure can be described with the Frank–Kasper polyhedra known for intermetallic phases.A red Te 15 Frank–Kasper polyhedron with 26 triangular faces is penetrated by the blue Cu 29 cluster, and in the center of the total cluster the sixteenth Te atom is situated, to which three of the copper atoms are ://
Mori M () Synthesis of Natural Products via Palladium-Catalyzed Carbonylation. In: Negishi E, de Meijere A (eds) Handbook of Organopalladium Chemistry for Organic Synthesis. Wiley, New York, p One time-tested approach for determining the scope and limitations of new chemistry is to evaluate its utility for the synthesis of architecturally complex, polyfunctional natural ://
β-Lactams Versatile Building Blocks for the Stereoselective Synthesis of Non-β-Lactam Products - 百度首页 登录 加入VIP 享VIP专享文档下载特权 赠共享文档下载特权 w优质文档免费下载 赠百度阅读VIP精品版 立即开通 意见反馈 下载客户端 网页 The synthetic utility of the De Mayo reaction in natural product synthesis has been readily explored and early examples include hirsutene (), , loganin (), − reserpine (), , and zizaene () (Figure Figure10 10). , Another classical example employing an intramolecular [2 + 2] photocycloaddition followed by a
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We report the Lewis acid catalyzed additions of allylsilanes to N-Boc-iminooxindoles and the formation of novel silicon-containing spirocarbamates via intramolecular trapping of a β-silyl carbocation by an N-Boc group. Several transformations display the synthetic utility of these spirocarbamate oxindoles, including a reductive cyclization to access new silylated furoindoline :// Synthesis of natural products via intramolecular trapping of photogenerated ketenes Author: Winders, J.
ISNI: Awarding Body: University of Salford Synthesis ?uin= (Trialkylsilyl)arylketenes combine with (trimethylsilyl)diazomethane in a new [4 + 1] annulation process leading to 2-indanone derivatives.
The (trialkylsilyl)arylketene annulation substrates are available via the photochemical Wolff rearrangement of α-silyl-α-diazo ketones, which are themselves prepared by silylation of the corresponding diazo :// Synthesis of Natural Products via Nucleophilic Attack on π‐Ligands of Palladium–Alkene, Palladium–Alkyne, and Related π‐Complexes (Pages: ) Caiding Xu Ei‐ichi Negishi Catalytic Enantioselective Desymmetrization of 1,3-Diazidopropanol via Intramolecular Interception of Alkyl Azides with Diazo(aryl)acetates Recent Advances in the Synthesis of Natural Products and Related Scaffolds.
Yun Li, Hongjian Yang, Hongbin Zhai. Chemistry Enantioselective Trapping of Pd-Containing 1,5-Dipoles by Photogenerated A simple and efficient protocol for the regioselective synthesis of 5-aminooxazoles is disclosed.
The reaction, catalyzed by a cheap Cp*Co(III) catalyst, starts from easily accessible N-(pivaloyloxy)amides and ynamides. Mild reaction conditions, a broad substrate scope, good functional group tolerance, and good to excellent yields were Exposure of α-diazo thiol esters (1) to the action of catalytic rhodium(II) acetate leads to a remarkably facile “thia-Wolff rearrangement”, producing thio-substituted ketenes which combine with a variety of ketenophiles to provide access to α-thiocyclobutanones, cyclobutenones, and β-lactams.
Reductive desulfurization of these cycloadducts takes place under mild conditions and in Enantioselective Trapping of Pd-Containing 1,5-Dipoles by Photogenerated Ketenes: Access to 7-Membered Lactones Bearing Chiral Quaternary Stereocenters.
Journal of the American Chemical Society(1), DOI: /jacs.8b?src=recsys. Title:Hypervalent Iodine-Mediated Synthesis of Spiroheterocycles via Oxidative Cyclization VOLUME: 23 ISSUE: 1 Author(s):Linlin Xing, Yong Zhang and Yunfei Du* Affiliation:Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, TianjinTianjin Key Laboratory for Modern Drug Delivery & † Recent progress of c-glycosylation methods in the total synthesis of natural products and Li, C.
† Improved utilization of photogenerated charge using fluorine-doped tio 2 hollow spheres scattering layer Liu, X.-W. † Direct synthesis of pyrroles via a silver-promoted three-c omponent reaction i nvolving 蓝宇，重庆大学化学化工学院教授，博士生导师，国家自然科学基金优秀青年基金获得者，现任理论与计算化学重庆市重点实验室主任。蓝宇教授在理论计算有机化学、金属有机化学等领域从事多年 The intramolecular stereospecific cycloaddition of ketenes to olefins is a occurs via a sequential reduction/intramolecular aldol reaction.
for the synthesis of natural products and An efficient transition-metal-free photoinduced intracyclization of 4H-chromenones in EtOH–H2O (, v/v) at ambient temperature for the construction of complicated fused-ring heteroaromatics is established. The reaction proceeds smoothly without requiring any catalysts/ Diazo compounds have proven to be a useful class of carbenes or metal carbenoids sources under thermal, photochemical, or metal-catalyzed conditions, which can subsequently undergo a wide range of synthetically important transformations.
Recently, asymmetric photocatalysis has provoked increasing research interests, and great advances have been made in this discipline towards the synthesis of An asymmetric intramolecular Cannizzaro reaction of aryl and alkyl glyoxals with alcohols has been realized with an unprecedented high level of enantioselectivity, on the basis of a newly developed congested TOX ligand and a gradual liberation protocol of active glyoxals from glyoxal monohydrates.
Preliminary results suggested a mechanism of enantioselective addition of alcohols to A high-yielding, divergent approach to generate either spirocyclic indolenines or carbazoles from a common indole-tethered propargyl alcohol precursor is described, with mechanistic insight provided.
Either product can be obtained upon treatment with different Ag(I) catalysts at rt. An unexpected hydration reaction to afford (±)-actinopolymorphol B is also An expedient and economic approach for constructing O,O,N-spiro compounds consisting of both a 1,3-oxazine and a furan ring through a catalyst-free formal [4+1]/[4+2] cycloaddition cascade sequence of isocyanides with two molecules of acylketene formed in situ through thermal-induced Wolff rearrangement of 2-diazo-1,3-diketones was developed.
The reaction displayed good functional group A Rh(I)-catalyzed intermolecular cyclization between isocyanates and benzocyclobutenols leading to isoquinolin-1(2H)-ones through selective cleavage of a C–C bond has been realized.
Exploiting the same strategy, we developed a Rh(I)-catalyzed three-component reaction of benzocyclobutenols, isonitriles, and sulfonyl azides to access isoquinolin-1(2H):// A wide array of methods for allene synthesis have been reported, such as the substitution of propargylic electrophiles, isomerization of alkynes and sigmatropic rearrangement.
An alternative approach for the synthesis of allenes is 1,2-elimination of an appropriately substituted Cyclobutenone formation is often a minor reaction pathway observed in the coupling of Fischer carbene complexes with alkynes; however, in a very limited number of cases cyclobutenone formation is the major pathway (Scheme 50).Coupling of ferrocenylcarbene complex with alkynes led to predominantly cyclobutenones (e.g., ) and furans (e.g., ) and not benzannulation products.
The. A new, highly efficient, selective methodology for formation of medium-ring and macrocyclic lactones via intramolecular ketene trapping: An application to a convergent synthesis of (-)-kromycin A key feature of the synthesis is the construction of the trans-cyclobutane motif by a Wolff rearrangement with in situ catalytic, asymmetric trapping of the ://Fraile, Alberto; Alemán, José: Inter- and Intramolecular Dienamine Organocatalytic Strategies for the Synthesis of Tetrahydroisoquinolines and Tricyclic Derivatives via [3+2] and [4+2] Cycloadditions